Gene and use thereof

Details Gene and use thereof Gene and use thereof

2006-06-20

2006-06-20

Carlson, Karen Cochrane (Department: 1653)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S350000, C530S388220, C536S023500, C435S007200, C435S069100

Reexamination Certificate

active

07064106

ABSTRACT:
A protein and DNA encoding the same are useful as preventives/remedies for diseases such as hypoglycemia, etc. The protein of the present invention is also useful as a reagent for screening a compound that inhibits the binding of the protein of the present invention to IRAP (insulin responsive aminopeptidase) or to GLUT4 (glucose transporter 4). The compound that inhibits the binding of the protein of the present invention to IRAP or GLUT4 is useful as a preventive/remedy for diseases, e.g., hyperglycemia, diabetes mellitus, etc.

REFERENCES:
patent: WO 99/59560 (1999-11-01), None
patent: WO 00/12544 (2000-03-01), None
Westendorf, et al., “Identification and characterization of a protein containing formin homology (FH1/FH2) domains”, Gene 232 (1999), 173-182.
Wu-Wong, et al., “Endothelin Stimulates Glucose Uptake and GLUT4 Translocation via Activation of Endothelin ETAReceptor in 3T3-L1 Adipocytes★”, The Journal of Biological Chemistry, vol. 274, No. 12, Mar. 19, 1999, pp. 8103-8110.
Thurmond, et al., “Regulation of Insulin-stimulated GLUT4 Translocation by Munc18c in 3T3L1 Adipocytes★”, The Journal of Biological Chemistry, vol. 273, No. 50, Dec. 11, 1998, pp. 33876-33883.
Waters, et al., “The Amino Terminus of Insulin-responsive Aminopeptidase Causes Glut4 Translocation in 3T3-L1 Adipocytes★”, The Journal of Biological Chemistry, vol. 272, No. 37, Sep. 12, 1997, pp. 23323-23327.
EPO Communication dated May 27, 2004.
Ross, Stuart A. , “Increased Intracellular Sequestration of the Insulin-regulated Aminopeptides Upon Differentiation of 3T3-L1 Cells,”Biochemical Journal, vol. 330, No. 2, pp. 1003-1008, XP-0021252805, 1998.

Affiliated with

Also associated with

Rating

Gene and use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Gene and use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Gene and use thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3649170