Multicellular living organisms and unmodified parts thereof and – Plant – seedling – plant seed – or plant part – per se
Reexamination Certificate
2008-03-11
2008-03-11
Carlson, Karen Cochrane (Department: 1656)
Multicellular living organisms and unmodified parts thereof and
Plant, seedling, plant seed, or plant part, per se
C435S320100, C435S325000, C530S300000, C536S023100
Reexamination Certificate
active
10500361
ABSTRACT:
This invention relates to a peptide or protein capable of converting a transcription factor into a transcriptional repressor, a gene encoding such peptide or protein, a chimeric protein in which the aforementioned peptide or protein is fused to a transcription factor, a chimeric gene in which the gene encoding a peptide or protein is fused to a gene encoding a transcription factor, a recombinant vector having such chimeric gene, and a transformant comprising such recombinant vector. The peptide of the invention that is capable of converting a transcription factor into a transcriptional repressor is very short. Thus, it can be very easily synthesized, and it can effectively and selectively repress the transcription of a specific gene. Accordingly, such gene is applicable to and useful in a wide variety of fields, such as repression of the expression of cancerous genes and regulation of the expression of genes encoding pigment-metabolic enzymes.
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Keiichiro Hiratsu et al., “The SUPERMAN protein is an active repressor whose carboxy-terminal repression domain is required for the development of normal flowers”, FEBS Letters 514 (2002) 351-354.
Keiichiro Hiratsu et al., “Identification of the minimal repression domain of SUPERMAN shows that the DLELRL hexapeptide is both necessary and sufficient for repression of transcription inArabidopsis”, Biochemical and Biophysical Research Communications, 321 (2004) pp. 172-178.
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Hiratsu Keiichirou
Takagi Masaru
Carlson Karen Cochrane
Foley & Lardner LLP
GreenSogna, Inc.
National Institute of Advanced Industrial Science and Technology
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