Gene amplification assay for detecting tumor promoters

Details Gene amplification assay for detecting tumor promoters Gene amplification assay for detecting tumor promoters

1981-06-30

1984-04-10

Warden, Robert J.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 4, C12Q 168, C12Q 100

Patent

active

044422032

ABSTRACT:
A correlation between gene amplification and tumor promotion is disclosed herein. This correlation allows for a simple cellular assay that indicates whether a substance or process is a tumor promoter. This assay does not depend upon numerous biochemical processes that introduce uncontrolled and unascertained varibles into other cellular assays. This assay can also be used to determine whether a set of cells is abnormally genetically labile and therefore susceptible to cancer or genetic disease.

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A. Varshavsky, Proc. Natl. Acad. Sci. U.S.A., vol. 78, No. 6, pp. 3673-3677, 1981.
A. Varshavsky, Cell, vol. 25, pp. 561-572, 1981.

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