Geminally disubstituted indene derivatives

Details Geminally disubstituted indene derivatives Geminally disubstituted indene derivatives

1978-08-01

1980-08-19

Hines, Robert V.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

260326R, 260326D, 2603265C, 26034844, 26034852, 260349, 26050115, 26050118, 260559D, 260562B, 260566F, 2605676M, 2605705C, 2605706, 2605708R, 2605708TC, 260649R, 424267, 424274, 424329, 424330D, 546 15, 546203, 560 19, 568322, 568327, A01N 920, A01N 922, C07C 9122

Patent

active

042184720

ABSTRACT:
New geminally disubstituted indenes are of general formula I ##STR1## wherein each of R.sup.1 and R.sup.2 is hydrogen or R.sup.1 and R.sup.2 together form a direct bond or an alkylene group --(CH.sub.2).sub.n --, in which n is an integer from 1 to 4, R.sup.3 is hydrogen, C.sub.1-3 -alkoxy or halogen, and each of R.sup.4 and R.sup.5 is hydrogen or C.sub.1-4 -lower alkyl, or R.sup.4 and R.sup.5 together form an alkylene group --(CH.sub.2).sub.m --, in which m is an integer from 3 to 6; and the corresponding amine oxides, quaternary ammonium compounds and salts with physiologically acceptable acids.
The indenes find use in treating incontinence, as a mucous membrane decongestant, as a blood pressure reducing agent, as vasocostrictor or as an anti-reserpine agent.
The indenes may be prepared by processes known per se involving

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patent: 4127675 (1978-11-01), Murakami et al.
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