Chemistry: analytical and immunological testing – Biospecific ligand binding assay
Patent
1991-09-04
1993-10-26
Housel, James C.
Chemistry: analytical and immunological testing
Biospecific ligand binding assay
436825, 435 71, 435962, 435975, G01N 33566, G01N 3353
Patent
active
052565750
ABSTRACT:
A kit for inactivating interfering binding proteins in a immunoassay for a member of a specific binding pair (sbp). The method comprises including in an assay medium containing a sample suspected of containing an sbp member and an interfering binding protein an effective amount of a water soluble compound having two substituted or unsubstituted phenyl groups linked to a common atom. When the sbp member or its sbp partner has two phenyl groups linked to a common atom, the compound has a number of-groups other than hydrogen attached to the phenyl groups and the atom that differs by at least two from the number of such groups on the sbp member. When the sbp member or its sbp partner has two phenyl groups linked to a common atom and the binding protein is not an antibody, the compound has only one group other than hydrogen attached to a phenyl group or the common atom. The methods have particular application in avoiding-cross-reactivity of non-analyte materials in a sample with immunachemical reagents used in such assay. The methods-have application also in disrupting complexer between an analyte to be determined and other materials to that one can accurately determine the amount of an analyte in a sample.
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Hu Mae W.
Lin Cheng-I
Schulkamp Kirk
Ullman Edwin F.
Bosse Mark L.
Housel James C.
Leitereg Theodore J.
Ludlow Jan M.
Syntex (U.S.A.) Inc.
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