Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-08-07
2007-08-07
Davis, Zinna N. (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S217030, C514S227800, C514S231500, C514S252130, C514S326000, C514S422000, C540S463000, C544S060000, C544S141000, C544S372000, C546S192000, C548S518000, C548S541000
Reexamination Certificate
active
10481477
ABSTRACT:
The present invention relates compounds of the formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8, R9and R10represent a variety of substituents, ring A is a phenyl or pyridyl ring; d is zero, 1 or 2; and pharmaceutically acceptable salts and N-oxides thereof. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis or postherpetic neuralgia
REFERENCES:
patent: 5776959 (1998-07-01), Ferrendelli et al.
patent: WO 98 03493 (1998-01-01), None
patent: WO 01 87866 (2001-11-01), None
Koskinen et al., CA 1989:173728.
Ohba et al., CA 1991:247145.
Yui et al., CA 2000:583935.
Exhibit 1—STN search results for starting material.
Severini et al., The Tachykinin Peptide Family, Pharmacological Reviews 54(2):285-322 (2002).
Hollingworth, et al, Bioorganic & Medicinal Chemistry Letters, 16 (2006), 1197-1201.
“Label” information for Emend as of Jun. 30, 2006.
Castro Pineiro Jose Luis
Dinnell Kevin
Elliott Jason Matthew
Hollingworth Gregory John
Shaw Duncan Edward
Davis Zinna N.
Merck Sharp & Dohme Limited
Panzer Curtis C.
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