Gem-difluoro derivative of phenylacetamide and phenylacetic acid

Details Gem-difluoro derivative of phenylacetamide and phenylacetic acid Gem-difluoro derivative of phenylacetamide and phenylacetic acid

1996-09-17

2000-03-07

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

562444, 562449, 564163, 564168, 564169, 564170, C07C22900, C07C23300

Patent

active

060342668

ABSTRACT:
The present invention refers to novel gem-difluoro compounds of formula: ##STR1## wherein: R.sub.1 can be hydrogen, acyl or acyl substituted; R.sub.2 is hydrogen, lower alkyl, lower alkyl substituted, nitro, halogen, methylenedioxy, trifluoromethyl or OR';

REFERENCES:
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Welch, J.T., et al, "Fluorine in Broorganic Chemistry", Willey and sons, 1991.
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Boechat, et al: "Synthesis of a Series of Fluorinated Analogues of 2-Amidephenylacetic Acids", 11th European Symposium on Fluorine Chemistry, Sep. 17-22, 1995.
Koruov, A.M., et al, Tetrahedrou: Asymmetry, 1995, 6, 199.
Middleton, W.J. et al, E.M.J. Org. Chem; 1980,45,2883-2887.
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Programme, 11th European Symposium on Fluorine Chemistry, Bled, Slovenia, Sep. 17-22, 1995.

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