Gem-dichlorocyclopropanes as antitumor agents

Details Gem-dichlorocyclopropanes as antitumor agents Gem-dichlorocyclopropanes as antitumor agents

1995-01-20

1997-09-02

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ether doai

514717, 514718, 514719, 514736, 568631, 568644, 568774, 568775, 568807, A61K 31045

Patent

active

056632070

ABSTRACT:
Gem-Dichlorocyclopropanes (Analog II derivatives) which demonstrate antiproliferative activity toward MCF-7 cells, in vitro and are generally not reversed by estradiol or having intrinsic estrogenicity (except the hydroxyphenyl derivative Compound 30). In general the cyclopropane compounds have the formula: ##STR1## or any pharmaceutically acceptable salt thereof. X is selected from a group consisting of hydrogen and halogen atoms. The group R.sub.1 may he a hydrogen atom, an alkyl group, an acyl group, or an arylalkyl group. The group R.sub.2 may be a hydrogen atom, an unsubstituted aryl group or a substituted aryl group. The group R.sub.3 may be a hydrogen atom, an alkyl group, a cycloalkyl group, a substituted aryl group or an unsubstituted aryl group. The group R.sub.4 may be a hydrogen atom, an unsubstituted aryl group or a substituted aryl group. The R.sub.4 is absent when R.sub.3 is a cycloalkyl group having a first position carbon and a terminal position carbon bonded to the same carbon of the cyclopropane. Further, no more than any two of R.sub.2, R.sub.3 and R.sub.4 has an aryl group.

REFERENCES:
Magarian et al., "Synthesis of Cyclopropyl Analogs of Stilbene and Stilbenediol as Possible Antiestrogens", Journal of Pharmaceutical Sciences, vol. 64, No. 10, Oct. 1975, pp. 1626-1632 Oct. 1975.

Affiliated with

Also associated with

Rating

Gem-dichlorocyclopropanes as antitumor agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Gem-dichlorocyclopropanes as antitumor agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Gem-dichlorocyclopropanes as antitumor agents will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-308701