Gem cyclodialkylation of amines and amides

Details Gem cyclodialkylation of amines and amides Gem cyclodialkylation of amines and amides

1987-05-11

1989-01-17

Schwartz, Richard A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544330, 544331, 544336, 544405, 546105, 546184, 546192, 546193, 546203, 546240, 546245, 546251, 546260, 546281, 546314, 546344, 546346, 548400, 548529, 548540, 548560, 548562, 548564, 548574, 548577, 548578, 548579, C07D47334, C07D29502

Patent

active

047988940

ABSTRACT:
Compounds containing at least one N,N-dialkylatable amino or amido group (e.g., aniline, dodecylamine, acetamide) are converted in a highly efficient manner into gem cyclodialkylated compounds by reaction with an unstrained cyclic ether (e.g., tetrahydrofuran) or a polyol (e.g., 1,4-butane diol) cyclizable to an unstrained ether using titanium dioxide catalysts that have prior to use:

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