Gem cyclodialkylation of amines and amides

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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548322, 548540, 548562, 548563, 548564, 548570, 548577, 548579, C07D29502

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RE0328960

ABSTRACT:
Amines and amides are N,N-cyclodialkylated by reaction with an unstrained cyclic ether in the presence of a B-subgroup metal oxide alkylation catalyst, preferably a Group IV-B metal oxide such as titanium dioxide.

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