Gelonin immunotoxin

Details Gelonin immunotoxin Gelonin immunotoxin

1988-03-07

1989-12-19

Teskin, Robin

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

530387, 530388, 530389, 530391, 530396, 530828, 424 8591, 424 88, 514 2, 514 6, 514 8, A61K 3944, C07G 700

Patent

active

048884154

ABSTRACT:
Immunotoxins having improved toxic activity have the composition ##STR1## wherein Toxin-NH is a ribosome-inactivating protein containing no accessible sulfhydryl groups, n is an integer from 1 to 5, m is an integer from 1 to 5, and NH-Antibody is a monoclonal antibody specific to eucaryotic cells or antigens associated therewith. The immunotoxins are made by reacting the Toxin-NH with an iminothiolester salt to form a first conjugate, reacting the NH-Antibody with N-succinimidyl-3-(2-pyridyldithio) propionate to form a second conjugate, and reacting the two conjugates to form the immunotoxin.

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