Geldanamycin derivatives and antitumor drug

Details Geldanamycin derivatives and antitumor drug Geldanamycin derivatives and antitumor drug

1980-01-03

1981-04-14

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424263, 424267, 424274, 42424854, 2602393B, 2602393T, 260239BB, A61K 31395, C07D22506

Patent

active

042619890

ABSTRACT:
Geldanamycin derivatives the following formula ##STR1## wherein R.sup.1 represents a saturated alkylamino which should have at least two carbon atoms, an unsaturated alkylamino, a substituted lower alkylamino, cycloalkylamino, pyrrolidino or aralkylamino group or methoxy group; R.sup.2 represents hydrogen atom, a halogen atom or a lower mono or dialkylamino; when R.sup.1 is methoxy group, R.sup.2 is a halogen atom or lower alkylamino group, or ##STR2## and Geldanamycin derivative is 8,9-epoxy-Geldanamycin. The compounds are effective as antitumor drugs.

REFERENCES:
patent: 3987035 (1976-10-01), Rinehart et al.

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