Gelatin hard capsule containing crystalline hydrate of oral ceph

Details Gelatin hard capsule containing crystalline hydrate of oral ceph Gelatin hard capsule containing crystalline hydrate of oral ceph

1990-02-09

1991-05-21

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424453, 424408, B65B 5102

Patent

active

050173804

ABSTRACT:
An antibacterial, 7.beta.-[(Z)-2-(2-aminothiazol-4-yl)-4-carboxybut-2-enoylamino]-3-cephem-4 -carboxylic acid is stable in a (di or tri)-hydrate crystal form. A pharmacologically effective amount of this hydrate is filled in a gelatin hard capsule and sealed by a band of gelatin to make a stable composition for clinical use after storage for a long time.

REFERENCES:
patent: 3927195 (1975-12-01), Messora
patent: 4390694 (1983-06-01), Ohnishi
patent: 4634697 (1987-01-01), Hamashima
patent: 4731361 (1988-03-01), Hamashima
patent: 4748170 (1988-05-01), Hamashima
patent: 4756902 (1988-07-01), Harvey et al.
patent: 4820833 (1989-04-01), Crisp et al.
patent: 4844906 (1989-07-01), Hernelm et al.

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