Gelatin-encapsulated digoxin solutions and method of preparing t

Details Gelatin-encapsulated digoxin solutions and method of preparing t Gelatin-encapsulated digoxin solutions and method of preparing t

1974-10-16

1977-01-11

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

424182, 2065247, A61J 307, A61K 948, A61K 31705

Patent

active

040027180

ABSTRACT:
Digoxin solutions are disclosed which are compatible with gelatin and which are of relatively high concentration, thereby permitting encapsulation of therapeutic amounts of digoxin in soft gelatin capsules of moderate size. The digoxin is first micronized and then dissolved in a vehicle consisting predominately of polyethylene glycol having a molecular weight no greater than about one thousand and having a melting temperature no greater than about 35.degree. C., to provide a digoxin concentration of at least one-half milligram per milliliter and preferably one milligram per milliliter. Solutions composed of various solvent blends are disclosed, including solutions which are highly viscous (semi-solid) at room temperature.

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