Gelatin capsule

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Capsules

Patent

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Details

424451, 424452, 424455, A61K 948, A61K 966

Patent

active

047803169

ABSTRACT:
A pharmaceutical dosage unit form comprises one or more pharmaceutically active materials dissolved or suspended in a liquid polyethylene glycol and encapsulated in a soft gelatin capsule shell, in which the capsule shell comprises gelatin, a plasticizer therefor, and an embrittlement inhibiting composition comprising a mixture of sorbitol and at least one sorbitan. Preferably the polyethylene glycol also contains glycerin, sorbitol or propylene glycol.

REFERENCES:
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patent: 2847346 (1959-08-01), Vaughan
patent: 2870060 (1959-01-01), Bryan
patent: 2870062 (1959-01-01), Stanley
patent: 2889252 (1959-06-01), Valentine
patent: 3520971 (1970-07-01), Benford
patent: 3653934 (1972-04-01), Rolle
patent: 3656997 (1972-04-01), Cordes
patent: 3779942 (1973-12-01), Bolles
patent: 3784684 (1974-01-01), Bossert et al.
patent: 4002718 (1977-01-01), Gardella et al.
patent: 4088750 (1978-05-01), Cresswell et al.
patent: 4198391 (1980-04-01), Grainger
patent: 4366145 (1982-12-01), Stoopak et al.
patent: 4428927 (1984-01-01), Ebert et al.
Johnson et al., "The Comparability of Dosage Regimens of Lanoxin Tablets and Lanoxicaps," British Journal of Clinical Pharmacology 4, pp. 209-211 (1977).
Ebert, "Soft Elastic Gelatin Capsules: A Unique Dosage Form," reprints from Pharmaceutical Technology (Oct. 1977).

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