Gelatin based synthetic blood and a method of making the same

Details Gelatin based synthetic blood and a method of making the same Gelatin based synthetic blood and a method of making the same

1983-02-07

1985-09-03

Rosen, Sam

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514832, A61K 3712

Patent

active

045392048

ABSTRACT:
A composition of matter which comprises a synthetic whole blood useful as a replacement for whole mammalian blood and a method of making the same are disclosed. The method of manufacture makes use of two gelatins, two modified fluid gelatins, or one gelatin and one modified fluid gelatin of differing isoelectric points, and selected additives. The invention also contemplates the use of only one gelatin or only one modified fluid gelatin, plus lecithin. The invention also contemplates using stroma free hemoglobin, microencapsulated stroma free hemoglobin, or synthetic liposomes containing stroma free hemoglobin incorporated in either the coacervate phase or the coacervate system of this invention. The method yields a two phase liquid aqueous system which successfully duplicates the two phase heterogeneous physico-chemical system of naturally occurring whole blood. The disclosed composition possesses many of the physiological capabilities of whole human blood.

REFERENCES:
patent: 4001401 (1977-01-01), Bonsen
patent: 4002739 (1977-01-01), Turner et al.
Arthur Osol, ed., Remington's Pharmaceutical Sciences (Easton, Pennsylvania: Mack Publishing Co., 1975), p. 315.
Bucala et al.--Science, vol. 220, May 1983, pp. 965-967.
P. Lundsgaard-Hansen, M.D. and B. Tschirren, M.D., "Modified Fluid Gelatin as a Plasma Substitute", Blood Substitutes and Plasma Expanders, (New York: Alan R. Liss, 1978), p. 227.
Information in a letter to B. H. Gold, M.D. from H. U. Frey, M.D., Director of the Blood Transfusion Service, Central Laboratory, Berne, Switzerland, Dec. 6, 1982 and Jan. 5, 1983.
"Blood", Van Nostrand's Scientific Encyclopedia, 1968, pp. 214-215.
Gessner G. Hawley, ed., The Condensed Chemical Dictionary, 9th ed., (New York: Van Nostrand Reinhold Company, 1977), p. 213.
Watanabe et al.--Chem. Abst., vol. 81, (1974), p. 16715v.

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