Gelatin and lecithin based synthetic whole blood and a method of

Details Gelatin and lecithin based synthetic whole blood and a method of Gelatin and lecithin based synthetic whole blood and a method of

1984-06-07

1986-06-24

Rosen, Sam

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 78, A61K 3702, A61K 31685

Patent

active

045967881

ABSTRACT:
A composition of matter which comprises a synthetic whole blood useful as a replacement for whole mammalian blood and a method of making the same are disclosed. The method of manufacture makes use of two gelatins, two modified fluid gelatins, or one gelatin and one modified fluid gelatin of differing isoelectric points, and selected additives. The invention also contemplates the use of only one gelatin or only one modified fluid gelatin, plus lecithin. The invention also contemplates using stroma free hemoglobin, micro-encapsulated stroma free hemoglobin, or synthetic liposomes containing stroma free hemoglobin incorporated in either the coacervate phase or the coacervate system of this invention. The method yields a two phase liquid aqueous system which successfully duplicates the two phase heterogeneous physico-chemical system of naturally occurring whole blood. The disclosed composition possesses many of the physiological capabilities of whole human blood.

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R. A. Kahn et al., "Alternative Sources and Substitutes for Therapeutic Blood Components", Blood, The Journal of the American Society of Hemotology, vol. 66-1 (Jul. 1985, pp. 1-12.
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