Gel formulations containing growth factors

Details Gel formulations containing growth factors Gel formulations containing growth factors

1995-10-06

1998-01-06

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 21, 530399, 424 7808, 424 941, A61K 3800, C07K 1400, C07K 100, C07K 1700

Patent

active

057054851

ABSTRACT:
Gel formulations containing polypeptide growth factors having human mitogenic or angiogenic activity are provided. The gel formulations are useful for topical or incisional wound healing for cutaneous wounds, particularly in the anterior chamber of the eye. The gel formulations also comprise a water soluble, pharmaceutically or ophthalmically compatible polymeric material for providing viscosity within various ranges determined by the application of the gel. The gel formulations provide controlled release and increased contact time of the growth factor to the wound site.

REFERENCES:
patent: 4717717 (1988-01-01), Finkenaur
patent: 5124316 (1992-06-01), Antoniades et al.
patent: 5457093 (1995-10-01), Cini et al.
Johnsson et al. The EMBO Journal 3(5), 921-928, (1984).
"Hydrogels in Medicine and Pharmacy", vol. 2, in Polymers, ed. N. Peppas, pp. 116-124 (1987).

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