Gel formulations containing growth factors

Details Gel formulations containing growth factors Gel formulations containing growth factors

1993-10-12

1995-10-10

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 21, 530399, A61K 3800, C07K 1700, C07K 100, C07K 1400

Patent

active

054570930

ABSTRACT:
Gel formulations containing polypeptide growth factors having human mitogenic or angiogenic activity are provided. The gel formulations are useful for topical or incisional wound healing for cutaneous wounds, in the anterior chamber of the eye and other ophthalmic wound healing. The gel formulations also comprise a water soluble, pharmaceutically or ophthalmically compatible polymeric material for providing viscosity within various ranges determined by the application of the gel. The gel formulations provide controlled release and increased contact time of the growth factor to the wound site.

REFERENCES:
patent: 3608070 (1971-09-01), Nouvel
patent: 4100271 (1978-07-01), Krozanoski
patent: 4534959 (1985-08-01), Schmolka
patent: 4717717 (1988-01-01), Finkenaur
patent: 4767628 (1988-08-01), Hutchinson
patent: 4806523 (1989-02-01), Bentz
patent: 5124316 (1992-06-01), Antoniades
patent: 5165938 (1992-11-01), Knighton
Johnsson et al., The EMBO Journal, 3(5), 921-928, 1984.

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