Gel-forming reagents and uses thereof for preparing microarrays

Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Polymers from only ethylenic monomers or processes of...

Reexamination Certificate

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C526S303100, C526S304000, C526S307000, C526S307300, C526S307400, C526S319000, C526S320000

Reexamination Certificate

active

07829644

ABSTRACT:
New gel-forming reagents including monomers and cross-linkers, which can be applied to gel-drop microarray manufacturing by using co-polymerization approaches are disclosed. Compositions for the preparation of co-polymerization mixtures with new gel-forming monomers and cross-linker reagents are described herein. New co-polymerization compositions and cross-linkers with variable length linker groups between unsaturated C═C bonds that participate in the formation of gel networks are disclosed.

REFERENCES:
patent: 4600641 (1986-07-01), Ogawa et al.
patent: 5702696 (1997-12-01), Mandeville et al.
patent: 6174683 (2001-01-01), Hahn et al.
patent: 6521431 (2003-02-01), Kiser et al.
patent: 6656725 (2003-12-01), Mirzabekov et al.
patent: 6692972 (2004-02-01), Yershov et al.
patent: 2004/0241713 (2004-12-01), Mirzabekov et al.
patent: WO 2005/120701 (2005-12-01), None
Beaucage, “Strategies in the Preparation of DNA Oligonucleotide Arrays for Diagnostic Applications,”Current Medicinal Chemistry, 8: 1213-1244 (2001).
Boncheva et al., “Design of Oligonucleotide Arrays at Interfaces,”Langmuir, 15: 4317-4320 (1999).
Broude et al., “DNA microarrays with stem-loop DNA probles: preparation and applications,”Nucleic Acids Research, 29(19): e92 (2001).
Campas et al., “DNA biochip arraying, detection and amplification strategies,”Trends in Analytical Chemistry, 23 (1): 49-62 (2004).
Charles et al., “Fabrication and Surface Characterization of DNA Microarrays Using Amine- and Thiol-Terminated Oligonucleotide Probes,”Langmuir, 19: 1586-1591 (2003).
Chrisey et al., “Covalent attachment of synthetic DNA to self-assembled monolayer films,”Nucleic Acids Research, 24 (15): 3031-3039 (1996).
Christensen et al., “Arrays in biological and chemical analysis,” Talanta, 56: 289-299 (2001).
Coffinier et al., “Semicarbazide-Functionalized Si(111) Surfaces for the Site-Specific Immobilization of Peptides,”Langmuir, 21: 1489-1496 (2005).
Guo et al., “Direct fluorescence analysis of genetic polymorphisms by hybridization with oligonucleotide arrays on glass supports,”Nucleic Acids Research, 22 (24): 5456-5465 (1994).
Houseman et al., “Carbohydrate Arrays for the Evaluation of Protein Binding and Enzymatic Modification,”Chemistry&Biology, 9: 443-454 (2002).
Joos et al., “Covalent Attachment of Hybridizable Oligonucleotides to Glass Supports,”Analytical Biochemistry, 247: 96-101 (1997).
Kelly et al., “Radical-generating coordination complexes as tools for rapid and effective fragmentation and fluorescent labeling of nucleic acids for microchip hybridization,”Analytical Biochemistry, 311: 103-118 (2002).
Kumar et al., “A Rapid Method for the Construction of Oligonucleotide Arrays,”Bioconjugate Chem., 14 (3): 507-512 (2003).
Predki, “Functional protein microarrays: ripe for discovery,”Current Opinion in Chemical Biology, 8: 8-13 (2004).
Raddatz et al., “Hydrazide oligonucleotides: new chemical modification for chip array attachment and conjugation,”Nucleic Acids Research, 30 (21): 4793-4802 (2002).
Rehman et al., “Immobilizatoin ofacrylamide-modified oligonucleotides by co-polymerization,”Nucleic Acids Research, 27 (2): 649-655 (1999).
Rogers et al., “Immobilization of Oligonucleotides onto a Glass Support via Disulfide Bonds: A Method for Preparation of DNA Microarrays,”Analytical Biochemistry, 266: 23-30 (1999).
Rubina et al., “Hydrogel-Based Protein Microchips: Manufacturing, Properties, and Applications,”BioTechniques, 34: 1008-1022 (2003).
Rubina et al., “Hydrogel drop microchips with immobilized DNA: properties and methods for large-scale production,”Analytical Biochemistry, 325: 92-106 (2004).
Soellner et al., “Site-Specific Protein Immobilization by Staudinger Ligation,”J. Am. Chem. Soc., 125: 11790-11791 (2003).
Talapatra et al., “Protein microarrays: challenges and promises,” Database: Future Medicine, 3 (4): 527-536 (2002) (Abstract).
van Berkum et al., “DNA microarrays: raising the profile,”Current Opinion in Biotechnology, 12: 48-52 (2001).
Vasiliskov et al., “Fabrication of Microarray of Gel-Immobilized Compounds on a Chip by Copolymerization,”BioTechniques, 27: 592-606 (1999).
Yershov et al., “DNA analysis and diagnostics on oligonucleotide microchips,”Proc. Natl. Acad. Sci., 93: 4913-4918 (1996).
Yousaf et al., “Diels-Alder Reaction for the Selective Immobilization of Protein to Electroactive Self-Assembled Monolayers,”J. Am. Chem. Soc., 121: 4286-4287 (1999).
Sage, “Biochips Go High-Tech,”Today's Chemist at Work, 44-48 (Jul. 2004).

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