Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – At least one aryl ring which is part of a fused or bridged...
Reexamination Certificate
2000-03-16
2002-08-13
Szekely, Peter (Department: 1714)
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
At least one aryl ring which is part of a fused or bridged...
C524S318000, C524S322000, C524S377000, C524S386000, C524S387000
Reexamination Certificate
active
06433054
ABSTRACT:
TECHNICAL FIELD
The present invention relates to a gel adhesive, an adhesive material containing that gel adhesive, and an adhering pharmaceutical preparation. More particularly, the present invention relates to a gel adhesive that is highly adhesive and is easily removable, a removable adhesive material having an adhesive surface that contains this gel adhesive that is used in applications such as protection of body skin, and an adhering pharmaceutical preparation that has an adhesive layer containing a pharmaceutical and the above-mentioned gel adhesive and can be removably adhered to the surface of body skin.
BACKGROUND ART
In recent years, various types of percutaneously absorbed tape preparations have been developed for administration of a drug into the body through the surface of the skin. Normally, such tape preparations preferably have necessary adhesive strength to prevent removal from the surface of the skin to which they are adhered, while also having an ease of removal to the extent that the skin surface (corneal layer) is not damaged when the tape preparation is removed after use.
In the case of rubber-based adhesives of the prior art, the addition of a liquid component such as liquid paraffin is used as means of preventing damage to the corneal layer of body skin during removal. However, in the case of using the above-mentioned adhesive of the prior art, it is necessary to add low molecular weight additives such as antioxidants and stabilizers, as well as adhesion-enhancing resins. Thus, even if it were possible to suppress removal of the corneal layer, it was difficult to suppress skin irritation.
Japanese Unexamined Patent Publication No. 60-208912 discloses a process for improving the stability of an adhesive by using polyester elastomer instead of natural rubber or synthetic rubber. In this, process, although the addition of antioxidant and stabilizer can be eliminated, it is necessary to add an adhesion-enhancing resin having a relatively low molecular weight (number average molecular weight<2000). Thus, skin irritation caused by this adhesion-enhancing resin could not be avoided.
In addition, Japanese Unexamined Patent Publication No. 62-230715 discloses a process for reducing skin irritation by using a base that reduces the adhesive strength (<300 g/12 mm) while not containing an adhesion enhancer by blending a non-adhesive thermoplastic urethane copolymer into an adhesive thermoplastic acrylic copolymer. In this process, however, since the adhesive strength of an adhesive resin is lowered by blending in a copolymer substantially without adhesive strength, and although this adhesive has the necessary adhesive strength to prevent removal from the contact surface of the skin, it is difficult to simultaneously demonstrate an ease of removal to the extent that the skin surface (corneal layer) is not damaged when the adhesive is removed after use.
Japanese Unexamined Patent Publication No. 3-220120 discloses an acrylic gel adhesive material in which a crosslinked gel layer, containing an acrylate ester polymer and a liquid component that is compatible with this polymer, is formed on at least one side of a support. According to this publication, since the gel adhesive is able to contain a large amount of a liquid component, it is possible to achieve a better balance between adhesive strength and removal ease than in non-crosslinked adhesives of the prior art, thereby making it possible to reduce removal of the corneal layer. In the gel adhesive of this publication, however, since the cohesive force of the adhesive is augmented, it is necessary to crosslink the acrylic acid units contained in the acrylate ester polymer in a chemical reaction with a low molecular weight crosslinking agent such as an alkolate of a polyvalent metal such as aluminum or titanium or a trifunctional isocyanate. In typical polymer reactions, since it is extremely difficult to achieve a reaction rate of 100%, and normally unreacted reaction components remain in the reaction system and, when these reaction products are used in a skin adhesion material, there is the risk of unreacted reaction components being percutaneously absorbed into the blood.
Japanese Unexamined Patent Publication No. 4-230212 discloses a process that allows a plastic active substance like a permeability promoter to be retained in an adhesive at high concentration without requiring additional chemical modification of a polyacrylate ester adhesive, wherein a polymethacrylatelester polymer, which although itself is not adhesive, but has extremely satisfactory film forming properties, is added to polyacrylate ester adhesive. However, in the case of adding a non-self-adhesive, film-forming polymethacrylate ester polymer to an adhesive polymer, although the cohesive strength of the adhesive polymer can be increased, the flexibility of the adhesive polymer (having a glass transition temperature of minus several tens °C.) ends up decreasing. Consequently, according to the process described in the above-mentioned publication, it is difficult to obtain an adhesive that simultaneously is easy to remove, to an extent that the skin surface (corneal layer) is not damaged, when it is removed following use. Moreover, since aluminum or titanium and so forth is added as a non-plastic assistant in all of the embodiments of this process, problems arise that are similar to those of the process described in the above-mentioned Japanese Unexamined Patent Publication No. 3-220120.
DISCLOSURE OF THE INVENTION
The object of the present invention is to provide a gel adhesive having removable adhesive strength and strong cohesive strength, an adhesive material containing that adhesive, and an adhering pharmaceutical preparation.
In addition, another object of the present invention is to provide a gel adhesive that stably retains its adhesive state to body skin, can be easily removed without damaging body skin as necessary, and does not remain adhered on the body skin during removal, an adhesive material containing that adhesive having high moisture permeability and able to protect body skin while not causing irritation or rash of body skin, and an adhering pharmaceutical preparation that allows a desired pharmaceutical to be absorbed into the body through body skin.
The above-mentioned objects can be achieved by the gel adhesive, adhesive material containing that gel adhesive, and adhering pharmaceutical preparation of the present invention.
The gel adhesive of the present invention contains an elastomer component (A), a self-adhesive polymer component (B) compatible with said elastomer component (A), and a liquid component (C) compatible with said elastomer component (A) and said self-adhesive polymer component (B) to form an adhesive gel; said liquid component (C) being held in a mixture of said elastomer component (A) and said adhesive polymer (B) without exuding.
In the gel adhesive of the present invention, the mixing weight ratio (B)/(A) of said self-adhesive polymer component (B) to said elastomer component (A) is preferably from 1.0:2.0 to 1.0:0.1, and the mixing weight ratio [(A)+(B)]/(C) of the total weight of said elastomer component (A) and said self-adhesive polymer component (B) to said liquid component (C) is preferably from 1.0:0.1 to 1.0:2.0.
In the gel adhesive of the present invention, said elastomer component (A) preferably contains at least one type selected from the group consisting of polyurethane elastomer, polyester elastomer and polyamide elastomer, said self-adhesive polymer component (B) preferably contains at least one type selected from the group consisting of acrylate ester polymer and vinyl acetate polymer, and said liquid component (C) preferably contains at least one type selected from the group consisting of liquid higher fatty acid ester, liquid higher fatty acid, liquid polyvalent alcohol and liquid polyvalent alcohol derivative.
The adhesive material of the present invention is formed and supported on a support and has a self-adhesive layer containing the above-mentioned, gel adhesive
Iwai Michio
Kawaguchi Takeyuki
Kuwahara Hiroaki
Maruo Susumu
Minematsu Hiroyoshi
Sughrue & Mion, PLLC
Szekely Peter
Teijin Limited
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