Gel filtration of factor VIII

Details Gel filtration of factor VIII Gel filtration of factor VIII

1993-01-04

1994-10-18

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530383, 424530, A61K 3514, C07K 1300, C07K 320

Patent

active

053568788

ABSTRACT:
Highly purified antihemophilic factor is produced by a process comprising a PEG precipitation step, a gel filtration step and a virus inactivation step. Al(OH).sub.3 adsorption and PEG precipitation carried out at room temperature allow processing to proceed directly to a gel filtration step.

REFERENCES:
patent: 4020713 (1977-05-01), Bick et al.
patent: 4670543 (1987-06-01), Bourgois et al.
patent: 4774323 (1988-09-01), Newman et al.
Thorell et al. "An In Vivo Study of a New Factor VIII Layer Purity Preparation", Thromb. Res vol. 31, pp. 375-385 (1983).

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