Gel-containing microcapillary column

Details Gel-containing microcapillary column Gel-containing microcapillary column

1991-04-19

1992-03-24

Niebling, John

Chemistry: electrical and wave energy

Processes and products

Electrostatic field or electrical discharge

204299R, G01N 2726, B01D 5702

Patent

active

050985396

ABSTRACT:
Disclosed is a gel-containing capillary column useful in high performance capillary electrophoresis. A preferred column includes a microcapillary having an interior cavity and a wall with an inner surface; a bifunctional agent comprising a positively charged amine adsorbed to the inner surface of the wall and an active functional group capable of copolymerizing with a polymeric gel material; and a polymer gel material filling the interior cavity of the microcapillary.

REFERENCES:
patent: 4680201 (1987-07-01), Hjerten
patent: 4865706 (1989-09-01), Karger et al.
patent: 4865707 (1989-09-01), Karger et al.
patent: 4997537 (1991-03-01), Karger et al.
patent: 5015350 (1991-05-01), Wiktorowicz
Hjerten, S., "High-Performance Electrophoresis Elimination of Electroendosmosis and Solute Adsorption"; J. Chron., 347:191-198 (1985).
Cobb, K. A., et al; "Electrophoretic Separation of Proteins in Capillaries with Hydrolytically Stable Surface Structures"; Anal. Chem. 62:2478-2483 (1990).

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