Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2006-02-14
2006-02-14
Siew, Jeff (Department: 1642)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C530S327000
Reexamination Certificate
active
06998237
ABSTRACT:
The present invention provides peptide mimics for GD3 ganglioside. The peptide mimics were identified by panning phage display peptide libraries with an anti-GD3 monoclonal antibody. The peptide mimics inhibit the binding of an anti-GD3 antibody to GD3 positive cells and also elicit antibodies which can bind to GD3 positive cells. The identified peptide mimics can be used as immunogens for cancer therapy.
REFERENCES:
patent: 5807978 (1998-09-01), Kokolus et al.
patent: 5882654 (1999-03-01), Morton
patent: 1279677 (2003-01-01), None
patent: WO 200038515 (2000-07-01), None
patent: WO 200181371 (2001-11-01), None
Willers et al. (Peptides 1999; 20: 1021-1026).
Chapman et al.,Vaccination with a Bivalent GM2and GD2Ganglioside Conjugate Vaccine: A Trial Comparing Doses of GD2-Keyhole, Clinical Cancer Research (Dec. 2000) vol. 6, pp. 4658-4662.
Grant et al.,Long Survival of Pateints with Small Cell Lung Cancer after Adjuvant Treatment with the Anti-Idiotypic Antibody BEC2 Plus Bacillus Calmette-Guérin, Clinical Cancer Research (Jun. 1999) vol. 5, pp. 1319-1323.
Lesinski et al.,A DNA Vaccine Encoding a Peptide Mimic of Streptococcus Pneumoniae Serotype 4 Capsular Polysaccharide Induces Specific Anti-Carbohydrate Antibodies in Balb/c Mice, Vaccine (2001) vol. 19, pp. 1717-1726.
Luo et al.,A Molecular Basis for Functional Peptide Mimicry of a Carbohydrate Antigen, The Journal of Biological Chemistry (May 26, 2000) vol. 275, No. 21, pp. 16146-16154.
McCaffery et al.,Immunization of Melanoma Patients with BEC2 Anti-Idiotypic Monoclonal Antibody That Mimics GD3 Ganglioside: Enhanced Immunogenicity WhenCombined with Adjuvant, Clinical Cancer Research (Apr. 1996) vol. 2, pp. 679-686.
Qiu et al.,Towards the Development of Peptide Mimotopes of Carbohydrate Antigens as Cancer Vaccines, Hybridoma (1999) vol. 18, No. 1, pp. 103-112.
Yao et al.,Immunization of Melanoma Patients with BEC2-Keyhole Limpet Hemocyanin Plus BCG Intradermally Followed by Intravenous Booster Immunizations with BEC2 to Induces Anti-GD3 Ganglioside Antibodies, Clinical Cancer Research (Jan. 1999) vol. 5, pp. 77-81.
Chi-Feng Hsu Jeff
Ferrone Soldano
Luo Wei
Tsao Chun-Yen
Wang Xinhui
Fetterolf Brandon
Health Research , Inc.
Hodgson & Russ LLP
Siew Jeff
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