GD2 peptide mimics

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 15 to 23 amino acid residues in defined sequence

Reexamination Certificate

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C530S300000, C514S002600, C514S014800

Reexamination Certificate

active

06939948

ABSTRACT:
The present invention provides peptide mimics for GD2 ganglioside. The peptide mimics were identified by panning phage display peptide libraries with an anti-GD2 monoclonal antibody. The identified peptide mimics can be used as immunogens for cancer therapy such as for melanoma and neuroblastoma.

REFERENCES:
patent: 5807978 (1998-09-01), Kokolus et al.
patent: 5882654 (1999-03-01), Morton
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Cheung et al.,Induction of Ab3 and Ab3' Antibody was Associated with Long-Term Survival after Anti-GD2 Antibody Therapy of Stage 4 Neuroblastoma, Clinical Cancer Research (Jul. 2000) vol. 6, pp. 2653-2660.
Kramer et al.,Disialoganglioside GD2 Loss Following Monoclonal Antibody Therapy is Rare in Neuroblastoma, Medical and Pediatric Oncology (2001) vol. 36, pp. 194-196.
Kushner et al.,Phase II Trial of the Anti-GD2 Monoclonal Antibody 3F8 and Granulocyte-Macrophage Colony-Stimulating Factor for Neuroblastoma, Journal of Clinical Oncology (Nov. 15, 2001) vol. 19, No. 22, pp. 4189-4194.
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Sorkin et al.,Antibody Directed Against GD2 Produces Mechanical Allodynia, but Not Thermal Hyperalgesia when Administered Systemically or Intrathecally Despite its Dependence on Capsaicin Sensitive Afferents, Brain Research (2002) vol. 930, pp. 67-74.
Tai et al.,Immunogenicity of Melanoma-Associated Gangliosides in Cancer Patients, Int. J. Cancer (1985) vol. 35, pp. 607-612.
Yu et al.,Phase 1 Trial of a Human-Mouse Chimeric Anti-Disialoganglioside Monoclonal Antibody ch14.18 in Patients with Refractory Neuroblastoma and Osteosarcoma, Journal of Clinical Oncology (Jun. 1998) vol. 16. No. 6, pp. 2169-2180.

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