gD-negative bovine herpesvirus mutant, capable of direct cell-to

Details gD-negative bovine herpesvirus mutant, capable of direct cell-to gD-negative bovine herpesvirus mutant, capable of direct cell-to

1995-07-18

1997-11-11

Mosher, Mary E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant virus encoding one or more heterologous proteins...

4242021, 4242291, 4352351, 536 2372, C12N 700, C12N 701, C12N 1538, A61K 39295

Patent

active

056860765

ABSTRACT:
The present invention relates to a gD-negative Bovine Herpesvirus mutant, that has the property of direct cell-to-cell transmission. The invention also relates to a DNA-fragment capable of conferring this property to Bovine Herpesviruses, not possessing the direct cell-to-cell transmission capability. Also, the invention relates to a vaccine based on this mutant, and a method for the protection of animals against Bovine Herpesvirus.

REFERENCES:
F. Fehler et al., Journal of Virology, 66:2:831-839, Fet. 1992.
S.K. Tikoo et al., Journal of Virology, 64:10:5132-5142, Oct. 1990.
Mettenlater et al 1994 J. Gen. Virol vol. 75:1723-1733.
Ligas et al 1988 J. Virol 62(5) 1486-1494.

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