gC1q receptor, HIV-1 gp120 region binding thereto, and related p

Details gC1q receptor, HIV-1 gp120 region binding thereto, and related p gC1q receptor, HIV-1 gp120 region binding thereto, and related p

1996-09-09

1998-04-14

Budens, Robert D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

4241851, 4241881, 4242081, 514 13, 514 14, 530326, 530327, 530395, 536 231, 536 2372, C07H 2104

Patent

active

057393060

ABSTRACT:
Disclosed are immunogens and peptides based on the binding site of gC1q-R for HIV-1 gp120, and immunogens and peptides based on the binding site of HIV-1 gp120 for gC1q-R. The sequence of the gC1q-R binding site for gp120 is shown in SEQ ID NO.: 2. The sequence of the HIV-1 gp120 binding site for gC1q-R is shown in SEQ ID NO.: 3. Also disclosed are antibodies and binding molecules to all such immunogens and peptides, and inducing the endogenous production of such antibodies.

REFERENCES:
patent: 4479934 (1984-10-01), Sedlacek et al.
patent: 4595654 (1986-06-01), Reckel et al.
Adrian R. Krainer et al., Cell 66: 383-94 (1991).
B. Honore et al., 134 Gene 283-287 (1993).
H.M. Geysen et al., PNAS USA 81:3998-4002 (1984).
B. Ghebrehiwet et al., J. Exp. Med. 179:1809-21 (1994).
T.B. Deb et al., J. Biol. Chem. 271:2206-12 (1996).

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