Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 15 to 23 amino acid residues in defined sequence
Patent
1996-09-06
1997-07-29
Budens, Robert D.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
15 to 23 amino acid residues in defined sequence
530810, 530812, 4241881, 4241931, C07K 708, A61K 3810
Patent
active
056523335
ABSTRACT:
Disclosed are immunogens and peptides based on the binding site of gC1q-R for HIV-1 gp120 and immunogens and peptides based on the binding site of HIV-1 gp120 for gC1q-R. The sequence of the gC1q-R binding site for gp120 is shown in SEQ ID NO.: 2. The sequence of the HIV-1 gp120 binding site for gC1q-R is shown in SEQ ID NO.: 3. Also disclosed are antibodies and binding molecules to all such immunogens and peptides, and inducing the endogenous production of such antibodies.
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Honore et al; "Cloning and Expression of a cDNA Covering the Complete Coding Region of the P32 Subunit of Human Pre-mRNA Splicing Factor SF2", Gene 134:283-287, 1993.
Shebrehivet et al; "Isolation cDNA Cloning and Overexpression of a 33-KD Cell Surface Glyco protein that Binds to the Globular Heads of C1g", J. Exp. Med 179:1809-1821, Jun. 1994.
Geysen et al; "Use of Peptide Synthesis to Probe Viral Antigens For Epitopes To A Resolution of a Single Amino Acid", Proc. Natl. Acad. Sci. USA 81:3998-4002, Jul. 1984.
Baran Deb et al; "Molecular Cloning of Human Fibrablast Hyaluronic Acid-binding Protein Confirms Its Identity With P-32, A Protein Co-Purified With Splicing Factor SF2," J. Biol. Chem. 271(4), 2206-2212, Jan. 26, 1996.
Fung Michael S. C.
Kim Young Woo
Sun Bill N. C.
Sun Cecily R. Y.
Yu Liming
Budens Robert D.
Mirabel Eric P.
Tanox Biosystems, Inc.
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