Gastroprotective pharmaceutical preparations containing N-benzyl

Details Gastroprotective pharmaceutical preparations containing N-benzyl Gastroprotective pharmaceutical preparations containing N-benzyl

1990-07-06

1993-08-03

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Identification or warning feature

Taste or smell or chemical irritation to the eye, nose, or...

5142388, 5142392, A61K 4900

Patent

active

052326861

ABSTRACT:
A method of inhibiting peripheral blood circulation disorders or damage such as hemorrhagic lesions induced by gastrotoxic doses of substances such as alcohol or non-steroid, antiinflammatory medicaments in the gastrointestinal tract of a mammal comprising administering to said mammal an effective peripheral circulation disorder or gastrointestinal damage inhibiting amount of a quaternary N-benzyl-N-{2-[2-((1S,5S)-6,6-dimethylbicyclo[3,1,1]hept-2-yl)-ethoxy]-eth yl}-morpholinium salt, and pharmaceutical compositions comprising a substance having a tendency to induce a peripheral blood circulation disorder or damage such as a hemorrhagic lesion in the stomach and/or intestinal wall of a mammal and an effective peripheral circulation disorder or gastrointestinal damage inhibiting amount of a quaternary N-benzyl-N-{2-[2-((1S,5S)-6,6-dimethylbicyclo[3,1,1]hept-2-yl)-ethoxy]-eth yl}-morpholinium salt.

REFERENCES:
patent: 3845048 (1974-10-01), Baronnet
patent: 4048313 (1977-09-01), Vincent et al.
Bert Rond et al 96CA:974662 1982.
Merck Index 10 ed #7315.
Foussard-Blanpin et al. 108CA:87864e 1988.
Marzio et al. 100CA:203463, 1984.
Droogmans et al., Naumyn-Schmiedeperg's ARch. of Pharmacol. 323:72-77 (1983).
Goodman and Gilman's The Pharmacological Basis of Terapeutics, p. 1746.

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