Gastrointestinal mucosa-adherent matrixes, pharmaceutical prepar

Details Gastrointestinal mucosa-adherent matrixes, pharmaceutical prepar Gastrointestinal mucosa-adherent matrixes, pharmaceutical prepar

1995-03-29

1996-11-19

Webman, Edward J.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424502, 424487, 514952, A61K 916

Patent

active

055760252

ABSTRACT:
A solid matrix composition which is solid at ambient temperature, which comprises a viscogenic agent, such as an acrylic acid polymer, capable of developing viscosity on contact with water, as dispersed at least in the neighborhood of the surface layer of a matrix particle containing a polyglycerol fatty acid ester or a lipid and an active ingredient. The matrix may be such that a matrix particle containing a polyglycerol fatty acid ester or a lipid and an active ingredient has been coated with a coating composition containing at least one viscogenic agent. Such composition can adhere to the digestive tract and remain there for a prolonged period of time, thereby increasing the bioavailability of the active ingredient. Solid preparations, such as fine granules and granules, contain the above matrix composition.

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