Gastrointestinal defensins, cDNA sequences and method for the pr

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Biocides; animal or insect repellents or attractants

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4351723, 4352523, 4353201, 536 235, 530324, 530350, 424 946, 514 12, 514 16, A01N 2500, C07H 2104, C07K 14435, C12N 1563

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active

056414978

ABSTRACT:
This invention provides gastrointestinal peptides useful as antimicrobial and anti-inflammatory agents. This invention also provides methods for producing peptides, pharmaceutical compositions containing the gastrointestinal defensin peptides, and methods of use thereof. Methods of diagnosing gastrointestinal disorders are also provided.

REFERENCES:
patent: 4677063 (1987-06-01), Mark
Mars et al Blood (1988) 71:1713-1719.
Moore et al J. Biol Chem (Oct. 1991) 266: 19851-19857.
Ouellette et al J Biol Chem (Jun. 1990) 265:9831-9837.
Fast DB sequence comparison.
Ouellette, et al., Febs Letters 304: 146-148 (1992).
Selsted, et al., Journal of Cell Biology 118: 929-936 (1992).
Bateman et al., J Biol Chem 266: 7524-7530 (1991).
Behnke and Moe, J Cell Biol 22: 633-652 (1964).
Bevins and Zasloff, Ann Rev. Biochem 59: 395-414 (1990).
Bohlmann and Apel, Mol Gen Genetics 207: 446-454 (1987).
Bohlmann et al., EMBO J 7: 1559-1565 (1988).
Bolivar et al., Gene 2: 95-113 (1977).
Boman, Cell 65: 205-207 (1991).
Boman & Hultmark, Ann Rev Microbiol 41: 103-126 (1987).
Borenstein et al., Infect Immun 59: 1359-1367 (1991).
Broach, J. et al., Gene 8: 121-133 (1979).
Broach, J.R., Meth Enz 101: 307-325 (1983).
Chamberlain et al., Nucleic Acids Research 16: 11141-11156 (1988).
Chamberlain et al., PCR Protocols: A Guide to Methods and Applications (Academic Press, Orlando, FL) 272-281 (1990).
Chen et al., Science 238: 263-366 (1987).
Clarke, L. et al., Meth Enz 101: 300-307 (1983).
Clewell, D.B., et al., Proc Natl Acad Sci USA 62: 1159-1166 (1969).
Clewell, D.B., J Bacteriol 110: 667-676 (1972).
Cohen, S., Proc Natl Acad Sci USA 69: 2110-2114 (1972).
Cotton et al., Proc Natl Acad Sci USA 85: 4397-4401 (1988).
Cowan et al., Mol Cell Biol 3: 1738-1745 (1983).
Daher et al., J. Virol 60: 1068-1074 (1986).
Daher et al., Proc Natl Acad Sci USA 85: 7327-7331 (1988).
Deckx et al., Biochim Biophys Acta 139: 204-207 (1967).
Devereux et al., Nucl Acids Res 12: 387-395 (1984).
Diamond et al., Proc Natl Acad Sci USA 88: 3952-3956 (1991).
Eisenhauer et al., Immun 57: 2021-2027 (1989)*.
Erlandsen et al., J Histochem Cytochem 22: 401-413 (1974).
Fiers et al., Nature 273: 113-120 (1978).
Frohman et al., Proc Natl Acad Sci USA 85: 8998-9002 (1988).
Fujiwara et al., J Biol Chem 265: 11333-11337 (1990).
Gabay et al., J Immunol 143: 1358-1365 (1989)*.
Ganz et al., Eur J Haematol 44: 1-8 (1990).
Ganz et al., J Clin Invest 76: 1427-1435 (1985).
Ganz et al., J Immunol 143: 1358-1365 (1989).
Geller and Thung, Arch Pathol Lab Med 107: 476-479 (1983).
Goeddel et al., Nucleic Acids Res 8: 4057-4074 (1980).
Graham and van der Eb, Virology 52: 456-467 (1973).
Gyllensten and Erlich, Proc. Natl. Acad. Science USA 85: 7652-7656 (1988).
Hertzog, Am J Pathol 13: 351-360 (1937).
Hill et al., Science 251: 1481-1485 (1991).
Hitzeman et al., J Biol Chem 255: 12073-12080 (1980).
Holland, M.J. et al., J Biol Chem 256: 1385-1395 (1981).
Holland et al., Biochemistry 17: 4900-4907 (1978).
Hsiao, C.L., et al., Proc Natl Acad Sci USA 76: 3829-3833 (1979).
Innis et al., Proc Natl Acad Sci USA 85: 9436-9440 (1988).
Joiner et al., J Cell Biol 109: 2771-2782 (1989).
Kagan et al., Proc Natl Acad Sci USA 87: 210-214 (1990).
Keshav et al., J Exp Med 171: 327-332 (1990).
Klockars and Reitamo, J Histochem Cytochem 23: 932-940 (1975).
Kozak, J Cell Biol 115: 887-903 (1991)*.
Lehrer, Hematol Oncol Clin North Am 2: 159-169 (1988).
Lehrer et al., J Virol 54: 467-472 (1985).
Lehrer et al., Cell 64: 229-230 (1991).
Lehrer et al., J Clin Invest 84: 553-561 (1989).
Lendrum, J Pathol Bacteriol 59: 399-404 (1947).
Lichtenstein, J Clin Invest 88: 93-100 (1991).
MacLeod et al., Proc Natl Acad Sci 88: 552-556 (1991).
Mars et al., Blood 71: 1713-1719 (1988).
Mars et al., Leukemia 1: 167-172 (1987)*.
Maxam et al., Methods in Enzymology 65: 499-560 (1980).
McBride et al., Clinical Chem 35: 2196-2201 (1989).
McDermid et al., Genomics 5: 1-8 (1989).
Messing et al., F. Supp. Nucleic Acids Res. 9: 309-321 (1981).
Matteucci et al., J Am Chem Soc 103: 3185-3191 (1981).
Myers et al., Nature 313: 495-498 (1985).
Myers et al., Science 230: 1242-1246 (1985).
Nakamura et al., J Biol Chem 263: 16709-16713 (1988).
Ohara et al., Proc Natl Acad Sci USA 86: 5673-5677 (1989).
Okrent et al., Am Rev Respir Dis 141: 179-185 (1990).
Olson and Samuelsson, Acta Chem Scand 26: 585-595 (1972).
Ouellette and Cordell, Gastroenterol 94: 114-121 (1988)*.
Ouellette and Lualdi, J Biol Chem 265: 9831-9837 (1990).
Ozaki et al., J Biochem 87: 549-555 (1980).
Paterson and Watson, Am J Pathol 38: 243-249 (1961).
Peeters and Vantrappen, Gut 16: 553-558 (1975).
Proudfoot and Brownlee, Nature 263; 211-214 (1976).
Reed and Mann, Nucl Acids Res 13: 7207-7221 (1985).
Rice, Blood 70: 757-765 (1987).
Riesner et al., Electrophoresis 10: 377-389.
Romeo et al., J Biol Chem 263: 9573-9575 (1988).
Rosenbaum and Riesner, Biophys Chem 26: 235-246 (1987).
Rossiter and Caskey, J Biol Chem 265 (22): 12753-12756 (1990).
Saiki et al., Science 239: 487-491 (1988).
Sambrook et al., Molecular Cloning: A Laboratory Manual Cold Spring Harbor, Cold Spring Harbor Laboratory Press (1989)*.
Sandow and Whitehead, Gut 20: 420-431 (1979).
Sanger, F. et al., Proc Natl Acad Sci USA 74: 5463-5467 (1977).
Satoh et al., Anatom Rec 225: 124-132 (1989).
Satoh and Vollrath, Anat Embryol 173: 317-322 (1986).
Satoh et al., Digestion 34: 115-121 (1986).
Schowalter et al., Genomics 6: 23-32 (1990).
Selsted et al., Infect Immun 45: 150-154 (1984).
Selsted and Harwig, Infect Immun 55: 2281-2286 (1987).
Selsted et al., J Biol Chem 260: 4579-4584 (1985).
Selsted et al., J Clin Invest 76: 1436-1439 (1985).
Selsted et al., J Biol Chem 258: 14485-14489 (1983).
Selsted and Harwig, J Biol Chem 264: 4003-4007 (1989).
Shaw, CH., et al., Gene 23: 315-330 (1983).
Shigenaga et al., J Biol Chem 265: 21350-21354 (1990).
Shimatake et al., Nature 292: 128-132 (1981).
Singh et al., Bioch Biophys Res Commun 155: 524-529 (1988).
Spitznagel, J. Clin Invest 86: 1381-1386 (1990).
Stinchchomb et al., Nature 282: 39-43 (1979).
Steiner et al., Nature 292: 246-248 (1981).
Stoflet et al., Science 239: 491-494 (1988).
Territo et al., J Clin Invest 84: 2017-2020 (1989).
Tissue Cultures, Academic Press, Cruz and Patterson, editors (1978)*.
Trier, J Cell Biol 18: 599-620 (1963).
Van Solingen, P., et al., J Bact 130: 946-947 (1977).
Wiedemann et al., Leukemia 3: 227-234 (1989).
Wilde et al., J Biol Chem 264: 11200-11203 (1989).
Zasloff, Proc. Natl Acad Sci USA 84: 5449-5453 (1987).

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