Gastro-protecting activity of substituted derivatives of 4-pheny

Details Gastro-protecting activity of substituted derivatives of 4-pheny Gastro-protecting activity of substituted derivatives of 4-pheny

1981-04-23

1983-09-06

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

424308, 424309, 424282, A61K 3119, A61K 31235, A61K 3124

Patent

active

044029780

ABSTRACT:
Diseases and ailments accompanied by gastric and gastroduodenal lesions treated by administering a compound of the formula (I) ##STR1## in which R represents hydrogen or alkyl containing 1 to 5 carbon atoms and R.sub.1 and R.sub.2, identical or different, both represent alkoxy containing 1 to 3 carbon atoms, or both represent halogen, or R.sub.1 represents hydrogen and R.sub.2 represents halogen, nitro or trifluoromethyl, or R.sub.1 and R.sub.2 form a methylenedioxy group at adjacent carbon atoms, in their racemic and optically active forms, as well as pharmaceutically acceptable salts thereof, particularly alkali metal, alkaline earth metal, or amine salts of said acid.

REFERENCES:
patent: 2532579 (1950-12-01), Thomas
patent: 2562208 (1951-07-01), Papa et al.
patent: 3753997 (1973-08-01), Ash et al.
patent: 3763148 (1973-10-01), Ash et al.
patent: 3846470 (1974-11-01), Raube et al.
patent: 3910959 (1975-10-01), Vallet
patent: 3940404 (1976-02-01), Ash et al.
patent: 3940487 (1976-02-01), La Croix et al.
patent: 3953463 (1976-04-01), Ash et al.
patent: 4017517 (1977-04-01), Murata et al.
Journal of American Pharmaceutical Association, vol. 37, No. 11, Nov. 1948, pp. 439-449.
Chemical Abstracts, vol. 88, No. 5, Jan. 30, 1978 Abstract 37442p.
Journal of the American Chemical Society, vol. 71, No. 4, Apr. 1949, F. K. Kirchner et al., pp. 1210-1213.
Journal of the American Chemical Society, vol. 70, No. 10, Oct. 1948, D. Papa et al., pp. 3356-3360.
European Journal of Medical Chemistry Chimica Therapeutica, vol. 12, Jan.-Feb. 1977, pp. 17-20.
European Journal of Medical Chemistry Chimica Therapeutica, vol. 13, No. 3, May-Jun. 1978, H. Orzalesi et al., pp. 259-264.
Beilstein, vol. 19, p. 312.
Journal of Pharmaceutical Sciences, vol. 66, No. 4, Apr. 1977, pp. 466-476, Child, Ralph G., et al., "Fenbufen, a New Anti-Inflammatory Analgesic: Synthesis and Structure--Activity Relationships of Analogs".
Journal of Medicinal Chemistry, vol. 15, No. 9, Sep. 1972, pp. 918-922, Markovac, A., et al.,--"Antimalarials 3, 2,6-Bis(aryl)-4-pyridinemethanols with Trifluoromethyl Substituents".
Journal of Organic Chemistry, vol. 35, No. 5, May 1970, pp. 1367-1376, Pettit, George R., et al., "Bufadienolides 1., Introduction and Base-Catalyzed Condensation of Methyl Ketonds with Glyoxylic Acid".
J.A.C.S., vol. 46, No. 10, Oct. 1924, pp. 2319-2326 Rice, Grace Potter, "The Isomeric Esters of Para-Ethoxy-Benzoylacrylic Acid".

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