Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 6 to 7 amino acid residues in defined sequence
Patent
1989-08-03
1991-09-10
Lee, Lester L.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
6 to 7 amino acid residues in defined sequence
530324, C07K 708, A61K 3700
Patent
active
050475029
ABSTRACT:
Small cell lung carcinoma cells (SCLC) contain gastrin releasing peptide (GRP) receptors. The response of the cells to GRP is rapid growth. We have found a group of heptapeptides that act as GRP antagonists by blocking the binding of GRP to its receptor thereby inhibiting the growth of cells that are sensitive to the growth promoting acitivity of GRP.
REFERENCES:
patent: 4350627 (1982-09-01), de Castiglione et al.
Marki et al., Peptides 2, Suppl. 2: 169-177 (1981).
Cuttitta et al., Nature, 316:823-826 (Aug. 29, 1985).
Garsky Victor M.
Heimbrook David C.
Oliff Allen I.
Riemen Mark W.
Davenport Avis
Grassler Frank P.
Lee Lester L.
Merck and Co., Inc.
Perrella Donald J.
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