Gastrin releasing peptide antagonist

Details Gastrin releasing peptide antagonist Gastrin releasing peptide antagonist

1988-05-24

1991-05-28

Russel, Jeffrey E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

6 to 7 amino acid residues in defined sequence

530309, 530345, C07K 706, C07K 730, A61K 3743

Patent

active

050196472

ABSTRACT:
Small cell lung carcinoma cells (SCLC) contain gastrin releasing peptide (GRP) receptors. The response of the cells to GRP is rapid growth. We have found a group of peptide derivatives that act as GRP antagonists by blocking the binding of GRP to its receptor thereby inhibiting the growth of cells that are sensitive to the growth promoting activity of GRP.

REFERENCES:
patent: 4435385 (1984-03-01), Bauer et al.
Jensen et al. (1984), Nature 309:61-63.
Marki et al. (1981), J. Am. Chem. Soc. 103:3178-85.
Thaisrivongs et al. (1989), J. Hypertension 1(suppl 2):S21-S23.

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