Gastrin and cholecystokinin receptor lignads (iv)

Details Gastrin and cholecystokinin receptor lignads (iv) Gastrin and cholecystokinin receptor lignads (iv)

2006-09-12

2006-09-12

Saeed, Kamal A. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S250000

Reexamination Certificate

active

07105558

ABSTRACT:
Compounds of the formula (I) or (II) and their pharmaceutically acceptable salts are ligands at gastrin and/or chole-cystokinin receptors n is from 1 to 4; R4is C1to C15hydrocarbyl wherein up to two C atoms may optionally be replaced by N, O and/or S atoms and up to three H atoms may optionally be replaced by halogen atoms; Z is —(NR5)a—CO—(NR6)b-(wherein a is 0 or 1, b is 0 or 1, and R5and R6are independently selected from H, Me, Et, Pr, Bn), —CO—NR5—CH2—CO—NR6—, —CO—O—, —CH2—CH2—, —CH═CH—, CH2—NR6— or a bond; Q is R7V, or(a) wherein R7is —CH2—; —CH2—; or(b) R7and R6, together with the nitrogen atom to which R6is attached, form a piperidine or pyrrolidine ring which is substituted by V; V is —CO—NH—SO2-Ph, —SO2—NH—CO-Ph, CH2OH, or a group of the formula —R8U, (wherein U is —COOH, tetrazolyl, —CONHOH— or —SO3H; and R8is a bond; C1to C6hydrocarbylene, optionally substituted by hydroxy, amino or acetamino; —O—(C1to C3alkylene)-; —SO2NR9—CHR10—; —CO—NR9—CHR10—, R9and R10being independently selected from H and methyl; or —NH—(CO)c—CH2—, c being 0 or 1); m is 1 or 2; q is from 0 to 2, with the proviso that q is 1 or 2 when Z is a bond); Compositions comprising a compound of formula (I) or (II) are also described.

REFERENCES:
patent: WO 95/30647 (1995-11-01), None
patent: WO 00/27823 (2000-05-01), None
Chemical Abstracts, vol. 80, No. 7, Feb. 18, 1974, Columbus, Ohio: Belikov et al., “Phenylhydrazones of alpha-keto acids.”, XP002172262.
Abdel-Fattach et al., “A New Route For the Synthesis of Fused Triazoles” Indian J. Chem. Sect. B. (1983), 22B(2) 125-7, XP001007419.
Settimo et al., “1,2,3-Triazole Derivatives of Salicylic Acid”, Farmaco, Ed. Sci. (1983), 38(10), 725-37, XP001007418.

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