Gastric-retentive, oral drug dosage forms for the controlled-rel

Details Gastric-retentive, oral drug dosage forms for the controlled-rel Gastric-retentive, oral drug dosage forms for the controlled-rel

1996-09-19

1999-10-26

Webman, Edward J.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424426, A61K 916, A61K 4734

Patent

active

059723890

ABSTRACT:
Controlled-release oral drug dosage forms that comprise a tablet or capsule containing a plurality of particles of a solid-state drug dispersed in a swellable/erodible polymer, such as poly(ethylene oxide) are described. Once ingested, the tablet or capsule disintegrates to disperse the particles within the stomach where they imbibe water to cause them to swell and promote retention in fed-mode-induced patients. As the gastric-retained dosage form gradually erodes, the drug is released in a controlled manner to the stomach for treatment of local disorders, and to the upper gastrointestinal tract where it becomes available for absorption in a controlled and therapeutic manner. Drug-containing vesicles, such as liposomes or nanoparticles or enteric-coated drug particles, can also be delivered to the gastrointestinal tract in a controlled manner using the gastric-retentive dosage forms of the present invention.

REFERENCES:
patent: 4404183 (1983-09-01), Kawata et al.
patent: 5007790 (1991-04-01), Shell
patent: 5273758 (1993-12-01), Royce
patent: 5545423 (1996-08-01), Soon-Shiong et al.
Davis, et al., "Transit of pharmaceutical dosage forms through the small intestine", Gut, 27 (8):886-892 (1986).
Fara, "Physiological limitations: gastric emptying and transit of dosage forms" in: Rate Control in Drug Therapy, L.F. Prescott, et al., Eds., Churchill Livingstone, New York (1985).
Hunt, et al., "A Relation Between the Chain Length of Fatty Acids and the Slowing of Gastric Emptying", J. Physiol., 194:327-336 (1968).
Meyer, "Gastrointestinal Structure and Function on Postcibal Transit of Food and Drug Particles" in: Drug Delivery to the Gastrointestinal Tract, J.G. Hardy, et al., Eds., Ellis Harwood, Ltd., Chichester, Chapter 3 (1989).
Sleisinger, Gastrointestinal Disease, 4th ed., W.B. Saunders, pp. 679-681 (1989).

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