Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...
Patent
1983-06-27
1984-09-11
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Reduced antigenicity, reduced ability to bind complement, or...
A61K 3700
Patent
active
044709749
ABSTRACT:
The somatostatin analog L-363,586 is a cyclic hexapeptide having the structure; cyclo-(N-methyl-Ala-Tyr-d-Trp-Lys-Val-Phe). L-363,586 has been found to be useful for inducing gastric cytoprotection via a mechanism not involving the inhibition of gastric acid secretions. Specific therapeutic utilities include, erosive gastritis, erosive esophagitis, inflammatory bowel disease and ethanol induced hemorrhagic gastric erosions.
REFERENCES:
patent: 4310518 (1982-01-01), Freidinger et al.
patent: 4370348 (1983-01-01), Shriver
Chem. Abstr. vol. 98, (1983) 84216j.
Biol. Abstr. 65, (1978) 64207.
Chem. Abstr. vol. 98, (1983) 752v.
Chem. Abstr. vol. 94, (1981) 76964d.
Chem. Abstr. vol. 91, (1979) 117810j.
Chem. Abstr. vol. 87, (1977) 63200g.
Chem. Abstr. vol. 89, (1978) 53800e.
S. Szabo et al., Experimentia 38, 254 (1982) "Cytoprotection-Organoprotection by Somatostatin . . . ".
S. Szabo et al., Science 214, 200 (1981) "Sulfhydryl Compounds May Mediate Gastric Cytoprotection".
Goldenberg Marvin M.
Keller Doris L.
Linek Ernest V.
Lopez Gabriel
Merck & Co. , Inc.
Pfeiffer Hesna J.
Phillips Delbert R.
LandOfFree
Gastric cytoprotection with L-363,586 does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Gastric cytoprotection with L-363,586, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Gastric cytoprotection with L-363,586 will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1194447