Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1992-06-05
1995-04-25
Kumar, Shailendra
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
12866001, 128601, 12866202, 424673, 514743, 514744, 514746, A61K 4900
Patent
active
054096880
ABSTRACT:
Disclosed herein are agents for enhancing the contrast in an ultrasound image. These agents are extremely small bubbles, or "microbubbles," comprised of specially selected gases. The microbubbles described herein exhibit long life spans in solution and may be produced at a size small enough to traverse the lungs, thus enabling improved ultrasound imaging of the cardiovascular system and other vital organs. Also disclosed herein is a method for selecting gases from which contrast agents may be produced. The method is based on calculations using inherent physical properties of gases and describes a means to associate the properties of a gas with the time for dissolution of microbubbles comprised of the gas.
REFERENCES:
patent: 4265251 (1981-05-01), Tickner
patent: 4276885 (1981-07-01), Tickner
patent: 4442843 (1984-04-01), Rasor et al.
patent: 4466442 (1984-08-01), Hilmann et al.
patent: 4533254 (1985-08-01), Cook et al.
patent: 4572203 (1986-02-01), Feinstein
patent: 4657756 (1987-04-01), Rasor et al.
patent: 4681119 (1987-07-01), Rasor et al.
patent: 4684479 (1987-08-01), D'Arrigo
patent: 4718433 (1988-01-01), Feinstein
patent: 4767610 (1988-08-01), Long
patent: 4774958 (1988-10-01), Feinstein
patent: 4832941 (1989-05-01), Berwing et al.
patent: 4844882 (1989-07-01), Widder et al.
patent: 4859363 (1989-08-01), Davis et al.
patent: 4895876 (1990-01-01), Schweighardt et al.
patent: 4900540 (1990-02-01), Ryan et al.
patent: 4927623 (1990-05-01), Long, Jr.
patent: 4957656 (1990-09-01), Cerny et al.
patent: 4987154 (1991-01-01), Long, Jr.
patent: 5078146 (1992-01-01), Sato
patent: 5088499 (1992-02-01), Unger
patent: 5107842 (1992-04-01), Levene et al.
patent: 5114703 (1992-05-01), Wolf et al.
patent: 5123414 (1992-06-01), Unger
patent: 5137928 (1992-08-01), Erbel et al.
patent: 5141738 (1992-08-01), Rasor et al.
patent: 5147631 (1992-09-01), Glajch et al.
patent: 5155215 (1992-10-01), Ranney
patent: 5171755 (1992-12-01), Kaufman et al.
patent: 5205290 (1993-04-01), Unger
patent: 5260496 (1993-11-01), Meinert et al.
patent: 5271928 (1993-12-01), Schneider et al.
patent: 5281408 (1994-01-01), Unger
patent: 5284645 (1994-02-01), Long
Keller et al. "Ultrasound Backscatter Characterizations of Sonicated Echo Contrast Agents" Abstracts of the 58th Scientific Sessions of the American Heart Association, Nov. 11-14, 1985, p. 427, Art. 1705 (Published in Part II, vol. 72, No. 4, Oct. 1985).
Widder et al. "Microbubbles as a Contrast Agent for Neurosonography and Ultrasound-Guided Catheter Manipulation: In Vitro Studies," AJNR May/Jun. 1986, pp. 347-352.
Keller et al. "Successful left ventricular opacification following peripheral venous injection of sonicated contrast agent: An experimental evalutation, "Am Heart J 1987; 114, pp. 570-575 (vol. 114, No. 3).
Ziskin et al. "Contrast Agents for Diagnostic Ultrasound," Ziskin, et al., Contrast Media For Ultra-sound, vol. No. 6, pp. 501-505 (Nov.-Dec. 1972).
Feinstein et al. "Safety and Efficacy of a New Transpulmonary Ultrasound Contrast Agent: Initial Multicenter Clinical Results," JACC vol. 16., No. 2, Aug. 1990, pp. 316-327.
Epstein et al. "On the Stability of Gas Bubbles in Liquid-Gas Solutions," J. App. Mech. 16, 277 (1949) pp. 1505-1509.
Meltzer et al. "Why Do the Lungs Clear Ultrasonic Contrast", Ultrasound in Med & Biol., vol. 6, pp. 263-269 (1980), pp. 263-269.
"Gas Encyclopaedia" English Translation by Nissim Marshall, Encyclopedie Des Geaz (1976).
Ultrasonics 1991, vol. 29, Jul. pp. 324-330 "Principles And Recent Developments In Ultrasound Contrast Agents" N. de Jong, et al.
Ultrasonics 1992, vol. 30 No. 2.pp 95-103 "Absorption And Scatter Of Encapsulated Gas Filled Microspheres: Theoretical Considerations And Some Measurements". N. de Jong et al.
Zarif et al., "Synergistic Stabilization of Perfluorocarbon-Pluronic F-68 Emulsion by Perfluoroalkylated Polyhydroxylated Surfactants", JAOCS, vol. 66, No. 10 (Oct. 1989).
Varescon et al., "An Easy, Convenient Way of Describing the Stability of Fluorocarbon Emulsions", Journal de chimie physique, 1989 86, n.degree. 10, pp. 2111-2116.
Handa et al., "Phospholipid Monolayers at the Trolein-Saline Interface: Production of Microemulsion Particle s and Conversion of Monolayers to Bilayers", Biochemistry 1990, 29, pp. 2884-2890.
Journal of Clinical & Laboratory Research Investigative Radiology, "Proceedings of The Association of University Radiologists Annual Meeting 1982", Jul.-Aug. 1982, vol. 17, No. 4, p. S28.
Mattrey et al., "Perfluoroctylbromide: A Liver/Spleen-Specific and Tumor-Imaging Ultrasound Contrast Material", Radiology 145:759-762, Dec. 1982.
Long, Jr. et al., "Experiments with Radiopaque Perfluorocarbon Emulsions for Selective Opacification of Organs and Total Body Angiography", Investigative Radiology, May-Jun. 1980, vol. 15, pp. 242-247.
Serratrice et al., "Co-solubilisation de fluorocarbures et d'eau en presence de nouveaux tensioactifs non ioniques fluores", J Chim Phys (1990) 87, pp. 1969-1980.
F. Szonyi et A. Cambon, "Sythesis de Tensioactifs F-Alkyles Non Ioniques Monodisperses", Journal of Fluorine Chemistry, 36 (1987), pp. 195-209.
A. S. Kabalnov, et al., "Solubility of fluorocarbons in water as a key parameter determining fluorocarbon emulsion stability" J. Fluorine Chemistry, 50:271-284 (1990).
H. J. Bleeker, et al., "Ultrasonic characterization of Albunex, a new contrast agent," J. Accoust. Soc. Am. 87(4) (1990).
R. Schlief, "Ultrasound contrast agents," Current Opinion in Radiology 3:198-207 (1991).
H. Bleeker, et al., "On the Application of Ultrasonic Contrast Agents for Blood Flowmetry and Assessment of Cardiac Perfusion," J. Ultrasound Med 9:461-471 (1990).
T. Ohta, et al., "Effect of the Contrast Agent and the Agitation Method on the Size, Number and Stability of Microbubbles: A Basic Experiment for the Myocardial Contrast Study," Jpn J Med Ultrasonics, 18:318-325 (1991).
S. B. Feinstein, et al., "Myocardial Contrast Echocardiography: Examination of Intracoronary Injections, Microbubble Diameters, and Video-Intensity Decay," Am. J. Physio. Imaging 1:12-18 (1986).
P. L. Davis, et al., "Echogenicity Caused by Stable Microbubbles in a Protein-Lipid Emulsion," Clin. Ultrasound 9:249-252 (1981).
V. F. Fobbe, et al., "Farbkodierte Duplexsonographic und Ultraschallkonstrastmittel-Nachweis von renalen Perfusionsdefekten im Tierexperiment", Fortschr. Rontgenstr. 154.3 242-245 (1991).
M. R. Violante, et al., "Particle-Stabilized Bubbles for Enhanced Organ Ultrasound Imaging," Invest. Radiology 26:194-200 (1991).
Ophir et al, Ultrasound in Med. & Biol. vol. 15, No. 14, pp. 319-333, 1989.
Kumar Shailendra
Sonus Pharmaceuticals Inc.
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