Gaseous microparticles as ultrasound contrast agents

Details Gaseous microparticles as ultrasound contrast agents Gaseous microparticles as ultrasound contrast agents

1995-06-05

1996-10-29

Burn, Brian M.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Ultrasound contrast agent

424 952, A61K 4900

Patent

active

055694497

ABSTRACT:
This invention relates to ultrasound contrast agents in the form of microparticles comprising a biotolerable matrix (e.g. of a carbohydrate or an X-ray contrast agent) in association with a gas or a precursor therefor. The contrast agents are stabilized to enhance their in vivo stability and/or echogenicity by covalently modifying the structure of the matrix, e.g. to introduce crosslinking groups or to attach lipophilic groups and/or molecules. The covalent moieties may include biodegradable linkages to assist rapid subsequent elimination of the contrast agents from the system.

REFERENCES:
patent: 4985233 (1991-01-01), Klaveness

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