Gaseous inhalable ultrasound contrast agents and method therefor

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Ultrasound contrast agent

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424 95, A61K 4904

Patent

active

060132434

ABSTRACT:
Inhalable ultrasound contrast imaging agents that are capable of forming microbubbles in vivo after administration to a patient are provided. The imaging agent is comprised of a gaseous mixture of an insoluble perfluorocarbon gas and at least about 20% oxygen by volume that is administered by a standard inhalation apparatus. Carbogen may be mixed with the insoluble perfluorocarbon gas in an amount sufficient to provide 20% oxygen by volume in the final gaseous mixture. A method of ultrasound imaging an individual by administering the gaseous composition of the invention to an individual by an inhalation apparatus and then subjecting the individual to an ultrasound scan is also provided.

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patent: 5417742 (1995-05-01), Tamhankar et al.
patent: 5705187 (1998-01-01), Unger

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