Gasci gene

Details Gasci gene Gasci gene

2006-09-12

2006-09-12

Huff, Sheela (Department: 1642)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S023500, C536S024300

Reexamination Certificate

active

07105649

ABSTRACT:
The invention provides, for example, a gene comprising a polynucleotide coding for the polypeptide having the amino acid sequence shown in SEQ ID NO:3. The gene shows amplification in the 9p23-24 region, has a PX domain and PHD finger motifs, plays an important role in cell growth and differentiation, and in tumorigenesis, and is useful in elucidating the pathology of various diseases caused by a protein involved in cell differentiation in malignant tumor or the like, and in the diagnosis and treatment of such diseases.

REFERENCES:
patent: 5928884 (1999-07-01), Croce et al.
patent: 6025480 (2000-02-01), Massague et al.
Nagase T., et al. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. Oct. 30, 1998;5(5):277-86.
Accession No.: AB018323 (1999).
Accession No.: AB037901 (BAB1602;200).
ID JJ2C-Human.
Yang ZQ, Imoto I, Fukuda Y, Pimkhaokham A, Shimada Y, Imamura M, Sugano S, Nakamura Y, Inazawa J. Cancer Res. Sep. 1, 2000;60(17):4735-9. Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in esophageal cancer cell .
Nagase, T. et al., “Prediction of the Coding Sequence of Unidentified Human Genes. The Complete Sequences of New cDNA Clones from Braun Which Code for Large Proteins in vitro”., DNA Research, (1998), vol. 5, No. 5, pp. 277-286.
Lock, P. et al., “A new method for isolating tyrosine kinase substrates used to identify Fish, an SH3 and PX domain-containing protein, and Src substrate”, The EMBO Journal, (1998), vol. 17, No. 15, pp. 4346-4357.
Yang et al., Identification of a Novel Gene,GASCI, within an Amplicon at 9p23-24 Frequently Detected in Esophageal Cancer Cell Lines.Cancer Res. 60:4735-4739 (2000).
Database EMBL ‘Online!’ Feb. 8, 2000, Accession No. AW402136.
Database EMBL ‘Online!’ Feb. 6, 2000, Accession No. AQ372902.
Database EMBL ‘Online!’ Feb. 6, 2000, Accession No. AW385519.
Database EMBL ‘Online!’ May 25, 2000, Accession No. AW887822.

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