Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Processes of preparing a desired or intentional composition...
Patent
1990-04-12
1994-08-16
Szekely, Peter
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
Processes of preparing a desired or intentional composition...
530812, 530815, 530816, 604265, 604266, A01N 100, A61M 2500
Patent
active
053387708
ABSTRACT:
The present invention is directed to thrombo-resistant coatings for use with gas permeable biomedical devices and implants. The coatings include a siloxane surface onto which a plurality of amine functional groups have been bonded. Covalently bonded to the amine functional groups are a plurality of poly(ethylene oxide) chains, such that a single poly(ethylene oxide) chain is bonded to a single amine functional group. A quantity of at least one bioactive molecule designed to counteract a specific blood-material incompatibility reaction is covalently bonded to the poly(ethylene oxide) chains, such that a single bioactive molecule is coupled to a single polyethylene oxide chain.
The methods of manufacturing the present invention include preparing a material having a siloxane surface onto which a plurality of amine functional groups have been bonded. This is preferably achieved by plasma etching with ammonia gas. The amine-containing siloxane surface is reacted with poly(ethylene oxide) chains terminated with functional groups capable of reacting with the amine groups on the siloxane surface. The material is then reacted with a solution of at least one bioactive molecule which counteracts a blood-material incompatibility reaction, such that a single bioactive molecule is coupled to a single poly(ethylene oxide) chain. The resulting siloxane surface is capable of resisting blood-material incompatibility reactions while maintaining high gas permeability.
REFERENCES:
patent: 3453194 (1969-07-01), Bennett et al.
patent: 3639141 (1972-02-01), Dyck
patent: 3826678 (1974-07-01), Hoffman
patent: 3846353 (1974-11-01), Grotta
patent: 3940506 (1976-02-01), Heinecke
patent: 3969240 (1976-07-01), Kolobow et al.
patent: 3992495 (1976-11-01), Sano et al.
patent: 4093515 (1978-06-01), Kolobow et al.
patent: 4170559 (1979-10-01), Kroplinski et al.
patent: 4210529 (1980-07-01), Petersen
patent: 4214020 (1980-07-01), Ward et al.
patent: 4243776 (1981-01-01), Marconi et al.
patent: 4483901 (1984-11-01), Okita et al.
patent: 4521564 (1985-06-01), Solomon et al.
patent: 4600652 (1986-07-01), Solomon et al.
patent: 4613517 (1986-09-01), Williams et al.
patent: 4613665 (1986-09-01), Larm
patent: 4622206 (1986-11-01), Torgeson
patent: 4666668 (1987-05-01), Lidorenko et al.
patent: 4673584 (1987-06-01), Nygren et al.
patent: 4770852 (1988-09-01), Takahara et al.
patent: 4781889 (1988-11-01), Fukasawa et al.
patent: 4806595 (1989-02-01), Noishiki et al.
patent: 4810784 (1989-03-01), Larm
patent: 4822741 (1989-04-01), Banes
patent: 4828561 (1989-05-01), Woodroof
patent: 4844986 (1989-07-01), Karakelle et al.
patent: 4846844 (1989-07-01), De Leon et al.
patent: 4861830 (1989-08-01), Ward, Jr.
patent: 4872867 (1989-10-01), Joh
patent: 4879135 (1989-11-01), Greco et al.
patent: 4919659 (1990-04-01), Horbett et al.
patent: 5004461 (1991-04-01), Wilson
patent: 5013717 (1991-05-01), Solomon et al.
patent: 5019393 (1991-05-01), Ito et al.
patent: 5026607 (1991-06-01), Kiezulas
patent: 5043278 (1991-08-01), Nagaoka et al.
patent: 5053048 (1991-10-01), Pinchuk
patent: 5053453 (1991-10-01), Ku
patent: 5061738 (1991-10-01), Solomon et al.
Berry Gaylord
Mortensen JD
Sanders Clifton G.
Solen Kenneth A.
Winters Suzanne
Cardiopulmonics, Inc.
Szekely Peter
LandOfFree
Gas permeable thrombo-resistant coatings and methods of manufact does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Gas permeable thrombo-resistant coatings and methods of manufact, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Gas permeable thrombo-resistant coatings and methods of manufact will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-952248