Surgery – Truss – Pad
Patent
1994-01-14
1996-01-30
Kulkosky, Peter F.
Surgery
Truss
Pad
424501, 42840222, A61B 814, A61K 950
Patent
active
054873908
ABSTRACT:
Compositions, methods for preparing and methods of using air-filled polymeric microcapsules for ultrasound imaging are disclosed. Air-encapsulating microcapsules are formed by ionotropically gelling synthetic polyelectrolytes such as poly(carboxylatophenoxy)phosphazene, poly(acrylic acid), poly(methacrylic acid) and methacrylic acid copolymers (Eudragit's) by contact with multivalent ions such as calcium ions. In the preferred embodiment, the average size of the microcapsules is less than seven .mu.m so that they are suitable for injection intravenously. The polymeric microcapsules are stable to imaging and display high echogenicity, both in vitro and in vivo. Due to their in vivo stability their potential application is extended beyond vascular imaging to liver and renal diseases, fallopian tube diseases, detecting and characterizing tumor masses and tissues, and measuring peripheral blood velocity. The microcapsules can optionally be linked with ligands that minimize tissue adhesion or that target the microcapsules to specific regions.
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Allcock Harry R.
Andrianov Alexander K.
Cohen Smadar
Langer Robert S.
Wheatley Margaret
Kulkosky Peter F.
Massachusetts Institute of Technology
The Penn State Research Foundation
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