Gas-exchange method of making gas-filled microspheres

Details Gas-exchange method of making gas-filled microspheres Gas-exchange method of making gas-filled microspheres

1995-06-07

1997-10-07

Holliden, Gary E.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Ultrasound contrast agent

12866202, A61K 4904, A61B 814

Patent

active

056744692

ABSTRACT:
Ultrasonic imaging agents comprising an insoluble gas may be made by a new process of gas exchange. A solution is supersaturated with the insoluble gas and then contacted with a conventional air-filled microsphere suspension in order to effectuate a gas exchange process. The insoluble gas-containing microsphere exhibits increased pressure resistance and stability over microspheres in which the gas exchange was performed passively.

REFERENCES:
patent: 4572203 (1986-02-01), Feinstein
patent: 4718433 (1988-01-01), Feinstein
patent: 5149543 (1992-09-01), Cohen et al.
patent: 5393524 (1995-02-01), Quay
patent: 5409688 (1995-04-01), Quay
patent: 5413774 (1995-05-01), Schneider et al.
Ophir et al., "Contrast Agents in Diagnostics Ultrasound." Ultrasound in Med. & Biol. 15(4):319-333 (1989).
Porter et al., "Visually Discernible Myocardial Echocardiographic Contrast After Intravenous Injection of Sonicated Dextrose Albumin Microbubbles Containing High Molecular Weight, Less Soluble Gases." J. of the American College of Cardiology 25(2):509-515 (1995).
March, Advanced Organic Chemistry, 4th Edition, pp. 417-418. John Wiley & Sons, New York, New York (1992).

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