Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1995-06-06
1999-09-21
Low, Christopher S. F.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 253, 536 252, 536 2432, 536 2431, 536 243, 536 242, 536 241, 435 911, 435 913, 435 9141, 935 3, 935 6, 935 8, C07H 2104
Patent
active
059555890
ABSTRACT:
Oligonucleotides and other macromolecules are provided which have increased nuclease resistance, substituent groups for increasing binding affinity to complementary strand, and subsequences of 2'-deoxy-erythro-pentofuranosyl nucleotides that activate RNase H. Such oligonucleotides and macromolecules are useful for diagnostics and other research purposes, for modulating the expression of a protein in organisms, and for the diagnosis, detection and treatment of other conditions susceptible to oligonucleotide therapeutics.
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Stawinski Jacek and Thelin Mats, Tenth
Cook Phillip Dan
Monia Brett P.
Isis Pharmaceuticals , Inc.
Low Christopher S. F.
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