Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2005-09-13
2005-09-13
Monshipouri, Maryam (Department: 1652)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S387900, C530S350000, C435S194000, C435S252300, C435S320100
Reexamination Certificate
active
06943237
ABSTRACT:
The object of the present invention is to provide a novel protein having a kinase activity and a gene encoding said protein. According to the present invention, there is provided a GANP protein which is represented by the amino acid sequence shown in SEQ ID No. 1 or No. 3 of the sequence listing, and is involved in the signal conversion of abnormal B cell differentiation in an autoimmune state, and has a kinase activity, and a polynucleotide which encodes said protein.
REFERENCES:
C. Thomas et al., “M17:a novel gene expressed in germinal centers”, International Immunology (1994), vol. 6, No. 8, pp. 1203-1211.
Ming-Jie Li, et al., “Rad51 expressio and localization in B cells carrying out class switch recombination”, Proc. Natl. Acad. Sci. USA (1996), vol. 93, No. 19, pp. 10222-10227.
Masaki Hikida et al., “Reexpression of RAG-1 and RAG-2 genes in activated mature mouse B cells”, Science (1996), vol. 274, No. 5295, pp. 2092-2094.
H. Shuhua, et al., “Neoteny In lymphyocytes: Rag1 and Rag2 expression in germinal center B cells”, Science (1996), vol. 274, No. 5295, pp. 2094-2097.
Kazuhiko Kuwahara et al., “Identification of a 52-kDa molecule coprecipltated with the lg receptor-related MB-1 protein that is Inducibly phosphorylated by the stimulation with phorbol myristate acetate”, J. Immunol. (1994), vol. 152, pp. 2742-2452.
Nagase et al., DNA Res., 5, 31-39, 1998.
Kuwahara Kazuhiko
Sakaguchi Nobuo
Immunokick Incorporation
McDermott Will & Emery LLP
Monshipouri Maryam
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