Gangliosides with immunosuppressive ceramide moieties

Details Gangliosides with immunosuppressive ceramide moieties Gangliosides with immunosuppressive ceramide moieties

1993-02-23

1994-11-22

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

424450, 536 41, 536 53, 536 55, 536 551, 536 552, 514 53, 514 61, A61K 3170

Patent

active

053669630

ABSTRACT:
A method for suppressing immune responses in animals by administering a mixture of gangliosides to the animal where the gangliosides have heterogeneous ceramide structures containing fatty acid portions with carbon chain lengths of 21-30 or less than 18 carbon atoms. Ganglioside mixtures which are homogeneous with respect to the fatty acid portion are also effective immunosuppressive agents when the carbon chain length of the fatty acid portion is less than 18. Compositions containing the above specified ganglioside mixtures are also disclosed.

REFERENCES:
patent: 4388309 (1983-06-01), Fabricius et al.
patent: 4593091 (1986-06-01), della Valle et al.
patent: 4639437 (1987-01-01), della Valle et al.
patent: 4728641 (1988-03-01), Tubaro et al.
patent: 4730058 (1988-03-01), Ogawa et al.
patent: 4762822 (1988-08-01), Ettinger
patent: 4849413 (1989-07-01), della Valle et al.
patent: 4868292 (1989-09-01), Yokoyama et al.
patent: 4880572 (1989-11-01), Fujita et al.
patent: 4914085 (1990-04-01), Ochi
patent: 4918170 (1990-04-01), Hasegawa et al.
patent: 4940694 (1990-07-01), della Valle et al.
patent: 4990603 (1991-02-01), Ogawa et al.
patent: 4990604 (1991-02-01), Ogawa et al.
Dyatlovitskaya et al; Biochim. Biophys. Acta 907:125-143 (1987).
Bergelson et al; Eur. J. Immunol. 19:1979-1983 (1989).
Grayson et al; Cellular Immunology 139:18-29 (1992).
The Merck Manual 16th Edition (1992) pp. 352-357.
Ladisch, Stephan et al., "Aberrant Fatty Acyl . . . ", The Journal of Biol. Chem., vol. 264, No. 20, pp. 12097-12105, 1989.
Geisler, Fred H., M.D. et al., "Recovery of Motor Function . . . " The New England Jour. of Med., vol. 324, No. 26, Jun. 27, 1991 (pp. 1829-1839).
Westrick, Mary Alice, et al., "Isolation and Characterization of Gangliosides . . . ", Cancer Research 43, 5890-5894, Dec. 1988.
Grassi, Fabio et al., "Chemical residues of ganglioside molecules . . . " Eur. J. Immunol. 1990.
Gonwa, Thomas Al., et al., "Inhibition of Mitogen--and Antigen-Induced Lymphocyte . . . ", Cancer Research 44, pp. 3467-3470 (1984).
Sonnino, Sandro, et al., "Preparation of GMl ganglioside molecular species . . . " Jour. of Lipid Research, vol. 26, 1985, pp. 248-257.
Presti, D. et al., "Lack of suppression by gangliosides of humoral . . . ", Jour. of Neurommunology, 22 (1989) pp. 233-239.
Kiso, Makoto, et al., "Synthesis of 1-O-(N-Acetyl . . . ", J. Carbohydrate Chemistry, 6(3), 411-422 (1987).
Dawson, Glyn, "Glycosphingolipid Function in Cancer", Cancer Cells, Oct. 1990, vol. 2, No. 10, pp. 327-328.
Cavaillon et al; Eur. J. Immunol. 16:1009-1012 (1986).
Ladisch et al; J. Clin. Invest. 79:1879-1882 (Jun. 1987).
Prokazova et al. Eur. J. Biochem. 172:1-6 (1988).
Floutsis et al.; Int. J. Cancer 43:6-9 (1989).
Hachida et al; Transplant Proc. 22(4):1663-1665 (Aug. 1990).
Agarwal et al; J. Immunol. 107(5):1448-1456 (1971).
Miceli et al; ACTA Psychiat. Scand. 55:102-110 (1977).
Yates et al.; Chemical Abstracts 93: 112178r (1980).
Whisler et al; J. Immunol. 125(5): 2106-2111 (1980).
Hakomori; Ann. Rev. Biochem. 50:733-764 (1981).
Ladisch et al.; Cancer Res. 43:3808-3813 (1983).
Ladisch et al.; J. Clin. Invest. 74:2074-2081 (1984).
Sugimoto et al; Carb. Res. 156:C1-C5 (1986).
Nakakuma et al.; FEBS 258:230-232 (1989).

Affiliated with

Also associated with

Rating

Gangliosides with immunosuppressive ceramide moieties does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Gangliosides with immunosuppressive ceramide moieties, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Gangliosides with immunosuppressive ceramide moieties will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1991526