Ganglioside derivatives

Details Ganglioside derivatives Ganglioside derivatives

1992-07-31

1994-09-27

Lilling, Herbert J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 84, 435101, 536 55, 536 551, 536 553, A61K 3170, C12P 1904, C07H 506

Patent

active

053508416

ABSTRACT:
Novel ganglioside derivatives comprised of a basic natural or semisynthetic ganglioside, in which the carboxyl group in the sialic part of the natural or semisynthetic ganglioside is converted into a carboxylamide with an aliphatic amino acid with a carboxylic or sulfonic acid function, and salts thereof are prepared. The semisynthetic ganglioside components can be chosen from the group consisting of N-acyl-N-lyso-gangliosides, N'-acyl-N'-lyso-gangliosides and N,N'-diacyl-N,N'-di-lyso-gangliosides, wherein "acyl" designates a moiety of an optionally substituted aliphatic acid. The ganglioside derivatives can be used in pharmaceutical preparations to be used in nervous system pathologies.

REFERENCES:
patent: 4713374 (1987-12-01), Della Valle et al.
patent: 4849413 (1989-07-01), Valle

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