Gamma-sorbitol polymorph

Details Gamma-sorbitol polymorph Gamma-sorbitol polymorph

1979-12-20

1981-02-24

Evans, Joseph E.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Free from infectious agents

568852, 424235, 424361, 426 3, 426660, C07C 3126, A21G 300, A61K 3100, A61K 4700

Patent

active

042527945

ABSTRACT:
A modified gamma-sorbitol polymorph having improved compressibility and hardness characteristics when formulated into a tablet while also exhibiting an absence or low degree of grit. Under a scanning electron microscope, the sorbitol polymorph of the invention is found to have a disrupted crystalline structure, substantial amounts of relatively large crystals not being coplanar with each other.

REFERENCES:
patent: 2755220 (1956-07-01), Alford et al.
patent: 3039927 (1962-06-01), Lafon
patent: 3445528 (1969-05-01), Hales
patent: 3973041 (1976-08-01), DuRoss

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