Chemistry: analytical and immunological testing – Biological cellular material tested
Reexamination Certificate
2007-07-18
2009-10-13
Bunner, Bridget E (Department: 1647)
Chemistry: analytical and immunological testing
Biological cellular material tested
C436S086000, C436S501000, C435S007100, C435S007920, C514S002600, C530S350000
Reexamination Certificate
active
07601540
ABSTRACT:
The present invention relates to the biomarker TFF-3 that measures γ-secretase mediated Notch processing. TFF-3 has utility in predicting and/or determining in vivo Notch-related toxicity associated with inhibition of Notch processing mediated by γ-secretase. The reagents and methods of the invention can be utilized before, after, or concurrently with, pre-clinical, clinical, and/or post-clinical testing. The reagents and methods of the invention can be used to identify and maintain preferred doses of test compounds and thereby prevent medical complications, such as gastrointestinal cellular damage.
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Denton Rex
Meredith Jere E.
Bristol--Myers Squibb Company
Bunner Bridget E
Golian Paul D.
Handler Melissa
LandOfFree
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